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Mol Pharmacol 51:370–376 Israel Y, Quintanilla ME, Sapag A, Tampier L 2006 Autosomal and maternal genes influence alcohol intake in alcohol drinker and nondrinker rat lines: role of the ‘acetaldehyde burst’. Alcohol Clin Exp Res 30:276A Oneta CM, Lieber CS, Li J et al 2002 Dynamics of cytochrome P4502E1 activity in man: induction by ethanol and disappearance during withdrawal phase. J Hepatology 36:47–52 Person RE, Chen H, Fantel AG, Juchau MR 2000 Enzymic catalysis of the accumulation of acetaldehyde from ethanol in human prenatal cephalic tissues: Evaluation of the relative contributions of CYP2E1, alcohol dehydrogenase, and catalase/peroxidases.

The generation of reactive oxygen species via oxidation of aldehyde by aldehyde oxidase and xanthine oxidase has been implicated in a number of pathological conditions including oxidative stress in the heart (Oei et al 1986), lipid peroxidation (Kato et al 1990, Kera et al 1988) and folate cleavage and release of iron (Shaw et al 1989, Shaw & Jayatilleke 1990a). In addition the metabolism of aldehydes has been implicated in mammary (Castro et al 2001a) and prostate (Castro et al 2001b) cancer as well as alcoholic pancreatitis (Nordback et al 1991).

I. Specificity and sigma-rho function. J Biol Chem 237:560–564 Deitrich RA, Collins AC, Erwin VG 1972 Genetic influence upon phenobarbital induced increase in rat liver supernatant aldehyde dehydrogenase activity. J Biol Chem 247: 7232–7236 Deitrich RA, Bludeau P, Stock T, Roper M 1977 Induction of different rat liver supernatant aldehyde dehydrogenases by phenobarbital and tetrachlorodibenzo-p-dioxin. J Biol Chem 252:6169–6176 Doorn JA, Hurley TD, Petersen DR 2006 Inhibition of human mitochondrial aldehyde dehydrogenase by 4-hydroxynon-2-enal and 4-oxonon-2-enal.

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