By P. Lechat, S. Thesleff and W. C. Bowman (Eds.)

Presents an in depth assessment of present learn into the organic results of aminopyridines and equally appearing elements. It specializes in their results on ion channels, and at the differences of contractility that they produce. The elements lined variety from biophysical stories of simple mechanisms of motion to the particular and power scientific makes use of in human sufferers

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Extra resources for Aminopyridines and Similarly Acting Drugs: Effects on Nerves, Muscles and Synapses. Proceedings of a IUPHAR Satellite Symposium in Conjunction with the 8th International Congress of Pharmacology, Paris, France, July 27–29, 1981

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B u l l . , 96^, 233-237 . U l b r i c h t , W. and H . - H . W a g n e r ( 1 9 7 6 ) . B l o c k of p o t a s s i u m c h a n n e l s of the n o d a l m e m b r a n e by 4 - a m i n o p y r i d i n e and its p a r t i a l r e m o v a l o n depolarization. , 367, 77. 87. V i e r h a u s , J. and W . U l b r i c h t ( 1 9 7 1 ) . R a t e of a c t i o n of t e t r a e t h y l ­ a m m o n i u m ions o n the d u r a t i o n of a c t i o n p o t e n t i a l s in s i n g l e R a n ­ vier nodes. Pflügers Arch.

H. Wagner and J. Schmidtmayer REFERENCES D u b o i s , J. M. ( 1 9 8 1 a ) . S i m u l t a n e o u s c h a n g e s in the e q u i l i b r i u m p o ­ t e n t i a l and p o t a s s i u m c o n d u c t a n c e in v o l t a g e c l a m p e d R a n v i e r nodes. J. P h y s i o l . ( L o n d . ) , (in p r e s s ) D u b o i s , J. M. ( 1 9 8 1 b ) . E v i d e n c e for the e x i s t e n c e of t h r e e t y p e s of p o t a s s i u m c h a n n e l s in the R a n v i e r n o d e m e m b r a n e . J.

S i ­ m i l a r e x p e r i m e n t s in o u r fast e x c h a n g i n g c u r r e n t c l a m p c h a m b e r , t o o , y i e l d e d v a r i a b l e r e s u l t s . W e m e a s u r e d the d u r a t i o n of a c t i o n p o t e n ­ t i a l s of a 1-Hz s e r i e s o n c h a n g i n g from 1 m M 4-AP + 1 m M T E A to 1 m M 4-AP. In s o m e (but n o t all) p r e p a r a t i o n s a transient shortening was o b s e r v e d w h i c h could i n d i c a t e s o m e d r u g i n t e r a c t i o n . I n c i d e n t a l l y , 1 m M T E A w a s m o r e e f f e c t i v e in i n c r e a s i n g the d u r a t i o n t h a n 1 m M 4-AP b u t less e f f e c t i v e t h a n the m i x t u r e .

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