By Shu-xin Zhang M.D., Ph.D. (auth.)

The starting pupil of histology is usually faced via a paradox: diagrams in lots of books that illustrate human microanatomy in a simplified, cartoon-like demeanour are effortless to appreciate, yet are tricky to narrate to real tissue specimens or photos. In flip, photos usually fail to teach a few vital positive aspects of a given tissue, simply because no person specimen can convey all the tissue's salient fea­ tures both good. This atlas, jam-packed with photo-realistic drawings, used to be ready to assist bridge the distance among the simplicity of diagrams and the extra complicated genuine­ ity of microstructure. all the figures during this atlas have been drawn from histological arrangements utilized by scholars in my histology sessions, on the point of sunshine microscopy. every one drawing isn't really easily an outline of anyone histological part, yet is usually a synthesis of the foremost buildings and lines noticeable in lots of arrangements of comparable tissues or organs. The illustrations are consultant of the common good points of every tissue and organ. The atlas serves as a compendium of the elemental morphological features of human tissue which scholars can be capable of recognize.

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Young chondrocytes undergo mitosis as they migrate to the deep portion of the cartilage from the periphery; thus, chondrocytes clustered in a single lacuna are known as an isogenous group. The cartilage matrix, containing amorphous ground substance and fibers, is basophilic because of the presence of glycosaminoglycans (hyaluronic acid and proteoglycans). The region surrounding the lacuna exhibits intense basophilia and is referred to as the cartilage capsule. Collagen fibers in the cartilage matrix are invisible in routine histological preparations because they have approximately the same refractive index as that of the surrounding intercellular substance.

Osteocytes '-", Bone p # # 0 G ~ G (£; Q - ~ Ruffled border Howship's lacuna O",obla", 45 46 3. Cartilage and Bone IFig. 3-11. t-- Bone Formation: Endochondral Ossification Formation of a long bone takes place by a process of endochondral ossification occurring within a hyaline cartilage model, which degrades to be replaced completely by newly formed bone. This includes the appearance of a primary ossification center in the middle of the diaphysis and a secondary ossification center in each epiphysis.

22 2. 1-- Loose Connective Tissue Loose connective tissue is important for nutrient and gas exchange and is always found in close association with epithelial tissues. Loose connective tissue is distributed in the papillary layer of the dermis, hypodermis, lamina propria, and telae submucosa. It also fills the gaps between organs and between tissues. Loose connective tissue is composed of several cell types and three kinds of fibers, in addition to the intercellular substance. These cell types include fibroblast, macrophage, adipose cell, plasma cell, mast cell, undifferentiated cell, lymphocyte, monocyte, and neutrophil.

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