By Verena Beier, Cora Mund, Jörg D. Hoheisel (auth.), Harald Seitz (eds.)

Analytics of Protein-DNA Interactions covers tendencies in glossy biotechnology. All elements of this interdisciplinary expertise, the place wisdom, equipment and services are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and laptop technological know-how, are handled. additional info in addition to the digital model is out there at springer.com.

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59 Abstract Gene families of recently duplicated but subsequently diverged genes provide an unique opportunity for comparative analysis of regulatory elements. We have studied the human SPRR gene family of small proline rich proteins involved in barrier function of stratified squamous epithelia. These genes are all expressed in normal human keratinocytes, but respond differently to environmental insults. Comparisons of the functional promoter regions allows the rapid identification of both conserved and of novel regulatory elements that appeared after gene duplication.

59 Abstract Gene families of recently duplicated but subsequently diverged genes provide an unique opportunity for comparative analysis of regulatory elements. We have studied the human SPRR gene family of small proline rich proteins involved in barrier function of stratified squamous epithelia. These genes are all expressed in normal human keratinocytes, but respond differently to environmental insults. Comparisons of the functional promoter regions allows the rapid identification of both conserved and of novel regulatory elements that appeared after gene duplication.

Differential Phylogenetic Footprinting . . . . . . . . . . . 5 Gene Family Footprinting . . . . . . . . . . . . . . Paralogous Genes Can Diverge in Coding Potential and Expression Pattern Molecular Changes in Paralogous Gene Regulation . . . . . . . Recently Duplicated Genes . . . . . . . . . . . . . . The Epidermal Differentiation Complex (EDC) . . . . . . . . CE Precursor Genes and “Fused Genes” . . . . . . . . . . 1 . 3 Proof-of-Principle: Novel Elements in the SPRR3 Promoter .

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